human papillomavirus prevalence and risk factors among hiv-negative and hiv-positive women residing in rural eastern cape, south africa

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ID: 146349
2020
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Abstract
Objectives: To investigate the prevalence of high-risk (HR) human papillomavirus (HPV) and factors associated with HR-HPV infection among women from rural Eastern Cape, South Africa. Methods: HPV prevalence was determined by Hybrid Capture 2 assay in cervical specimens from 417 women aged ≥30 years (median 46 years) recruited from the community health clinic in the Eastern Cape. Results: HR-HPV prevalence was 28.5% (119/417), and HIV-positive women had significantly higher HR-HPV prevalence than HIV-negative women (40.6%, 63/155 vs 21.4%, 56/262, respectively; p = 0.001). HIV-positive status (odds ratio (OR) 2.52, 95% confidence interval (CI) 1.63–3.90), having ≥3 lifetime sexual partners (OR 2.12, 95% CI 1.16–3.89), having ≥1 sexual partner in the last month (OR 1.89, 95% CI 1.21–2.92), ≥4 times frequency of vaginal sex in the past 1 month (OR 2.40, 95% CI 1.32–4.35), and having a vaginal discharge currently/in the previous week (OR 2.13, 95% CI 1.18–3.85) increased the risk of HR-HPV infection. In the multivariate analysis, HIV positivity remained strongly associated with HR-HPV infection (OR 1.94, 95% CI 1.17–3.22). Conclusions: Risk factors related to sexual behaviors play a significant role in HR-HPV infection in this population. This report will inform health policymakers on HPV prevalence and contribute to discussions on the use of HPV testing as the primary cervical cancer screening test in South Africa.
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taku2020internationalhuman Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ongeziwe Taku;Charles B. Businge;Mana L. Mdaka;Keletso Phohlo;Wisdom Basera;Mirta Garcia-Jardon;Tracy L. Meiring;Ulf Gyllensten;Anna-Lise Williamson;Zizipho Z.A. Mbulawa
Journal israel journal of chemistry
Year 2020
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S1201971220301090
Keywords
prevalence Risk factors hiv

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