15–lipoxygenase inhibition of commelina benghalensis, tradescantia fluminensis, tradescantia zebrina

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ID: 145910
2014
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Abstract
Objective: To evaluate the 15-lipoxygenase inhibitory activity of the methanol leaf extracts of Commelina benghalensis, Tradescantia fluminensis (T. fluminensis) and Tradescantia zebrina. Method: The inhibitory activity was evaluated using a spectrophotometric assay by observing the increase in absorbance at 234 nm due to the formation of the product 13-hydroperoxyoctadecadienoic acid. The extracts were also tested for the presence of terpenoids, saponins, tannins, flavonoids, steroids, phenolic compounds, alkaloids and cardiac glycosides. Results: All the extracts inhibited the action of 15-lipoxygenase at a concentration of 0.2 μg/mL. T. fluminensis and Tradescantia zebrina exhibited higher than 50% inhibition with T. fluminensis at 87.2%. T. fluminensis was partitioned with ethyl acetate and hexane and their IC50 values were determined at 8.72 μg/mL and 98.04 μg/mL, respectively. Conclusions: T. fluminensis is a potentially good source of 15-lipoxygenase inhibitors.
Reference Key
alaba2014asian15lipoxygenase Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Cean Socorro M. Alaba;Christine L. Chichioco-Hernandez
Journal Organic letters
Year 2014
DOI
10.1016/S2221-1691(14)60229-X
URL
http://www.sciencedirect.com/science/article/pii/S2221169115301908
Keywords
Medicinal Plants inflammation plant extracts 15-lipoxygenasearctic medicine

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