maintaining hepatic stem cell gene expression on biological and synthetic substrata

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ID: 145664
2012
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Abstract
The liver is a highly resilient organ that possesses enormous regenerative capacity. This is mediated mainly through the most abundant cell type found in the liver, the hepatocyte. When the regenerative capacity of the hepatocyte is compromised, during chronic or acute liver injury, hepatic progenitor cells (HPCs) are activated to replace the damaged tissue. The HPC resides in a laminin-rich environment; as HPCs differentiate toward a hepatic or biliary fate, the extracellular matrix (ECM) composition changes, influencing cell behavior. To assess the impact that the biological ECM and the synthetic ECM have on the maintenance of hepatic stem cell gene expression, a murine hepatic stem cell line was employed. We demonstrate that hepatic stem cell gene expression could be maintained using a biological or synthetic substratum, but not on plastic alone.
Reference Key
lucendo-villarin2012bioresearchmaintaining Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Baltasar Lucendo-Villarin;Ferdous Khan;Salvatore Pernagallo;Mark Bradley;John P. Iredale;David C. Hay
Journal Experimental lung research
Year 2012
DOI
10.1089/BIORES.2012.0206
URL
https://www.liebertpub.com/doi/full/10.1089/BIORES.2012.0206
Keywords
biological liver stem cell differentiation matrix

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