effect of hydroxyapatite on the physicochemical characteristics of a gentamicin-loaded monoolein gel intended to treat chronic osteomyelitis

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ID: 145431
2012
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Abstract
Many works have demonstrated the real potential of gentamicin-monoolein-water formulations as bioresorbable and sustained-release implants for the local treatment of the chronic osteomyelitis. In order to improve the efficacy of this type of implant, the incorporation of hydroxyapatite, a well-known osteointegrator material, is thought to be an interesting approach. Five formulations incorporating 0, 2.5, 5, 10, and 20% of hydroxyapatite were examined with regard to their physicochemical and in vitro drug release characteristics. The rheological, thermal (differential scanning calorimetric and thermogravimetric diffraction analysis), X-ray diffraction, and dissolution studies have showed that the presence of hydroxyapatite does not dramatically disturb the cubic liquid crystalline structure of the monoolein-water gel and their ability to progressively release the antibiotic. Implant 20% that was capable to release gentamicin sulfate over a period of four weeks without marked burst effect could be used as a more suitable biodegradable delivery system for the local management of chronic osteomyelitis.
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Authors ;Rasmané Semdé;Réné Flore Gueu Gondi;Bavouma Charles Sombié;B Gérard Josias Yaméogo;Moustapha Ouédraogo
Journal solid state communications
Year 2012
DOI
10.4103/2231-4040.97283
URL
http://www.japtr.org/article.asp?issn=2231-4040;year=2012;volume=3;issue=2;spage=100;epage=105;aulast=Semdé
Keywords
drug release implants pharmacologypharmacy and materia medica osteointegrator materialtherapeutics

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