evaluation of three commercially-available chikungunya virus immunoglobulin g immunoassays

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ID: 145402
2017
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Abstract
ABSTRACT The emergence of chikungunya virus in the Americas means the affected population is at risk of developing severe, chronic, rheumatologic disease, even months after acute infection. Accurate diagnostic methods for past infections are essential for differential diagnosis and consequence management. This study evaluated three commercially-available chikungunya Immunoglobulin G immunoassays by comparing them to an in-house Enzyme-Linked ImmunoSorbent Assay conducted by the Centers for Disease Control and Prevention (Atlanta, Georgia, United States). Results showed sensitivity and specificity values ranging from 92.8% – 100% and 81.8% – 90.9%, respectively, with a significant number of false-positives ranging from 12.5% – 22%. These findings demonstrate the importance of evaluating commercial kits, especially regarding emerging infectious diseases whose medium and long-term impact on the population is unclear.
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salazar2017revistaevaluation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Pablo M. De Salazar;Anne Marie Valadere;Christin H. Goodman;Barbara W. Johnson
Journal communications on pure and applied analysis
Year 2017
DOI
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URL
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892017000100408&lng=en&tlng=en
Keywords
diagnostic tropical medicinepublic aspects of medicine inmunoensayo de polarización fluorescente

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