aspectos da padronização de testes sorológicos para a doença de chagas: um teste imunoenzimático para a triagem de doadores de sangue standardization of serological tests in chagas' disease: immunoenzimatic test for screening of blood bank donnors
Article Quality & Performance Metrics
Readership in this journal
PopularRanked #51 of 173 articles by views in 2017 12th international conference for internet technology and secured transactions, icitst 2017
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 173 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
Abstract
In the serological diagnosis of Chagas disease large divergences may be found even between laboratories with experience, as a consequence of different criteria for the standardization of the tests. To standardize a immunoenzimatic test developed primarily for screening blood donors, serum panels were carefully chosen so as to best represent chagasic and non-chagasic populations. Produced for the highest sensibility and stability, the new reagent (bioELISA cruzi, Biolab Diagnóstica S/A, Brasil), was tested in serum from 1648 patients 219 with Chagas disease and 104 with other diseases, plus a comparison with well standardized immunofluorescence and hemagglutination tests in 1325 sera. In the immunoenzimatic assays, the cut off was indicated by the absorbance value of a chagasic serum showing a minimal reactivity. ELISA sensibility was 0,9954 and specificity 0,9969, as conegativity. False positive results were absent with sera from sifilis, toxoplasmosis, mononucleosis and high titered sera for antistreptolysin 0 antibodies. However they were seen in 5 to 15 cases of tegu-mentar leishmaniosis, 1 of 12 Kala-azar 1 of 15 reumatoid arthritis and 1 of 12 sistemic lupus erythematosus. The high sensibility in chagasics and high specificity in the general population indicate the confiability of the imunoenzimatic assay for screening blood donors and even to confirm a clinical diagnosis of Chagas' disease.
| Reference Key |
ferreira1991revistaaspectos
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | |
| Journal | 2017 12th international conference for internet technology and secured transactions, icitst 2017 |
| Year | 1991 |
| DOI |
10.1590/S0036-46651991000200006
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
ZincirX productsfrom the team behind Journament
-
PatentYazar
Patent drafts for the EPO, USPTO and TürkPatent
From inventor notes to a DOCX draft: description, claims, abstract. The machine drafts, the attorney signs.
See how it works (opens in a new tab) -
Projenator
Have a project idea? Score and plan it with AI
AI scores your idea in five dimensions and builds a phased plan. Your first project is free, no card needed.
Start your first project (opens in a new tab)
Cookies
We use strictly necessary cookies to run the site and keep you signed in. With your permission we would also use Google Analytics to see how the site is used, and Google AdSense to show ads on journal and article pages. Both stay off unless you accept, and you can change your mind at any time. How we use cookies · KVKK notice (Türkiye)
Cookie settings
Comments
No comments yet. Be the first to comment on this article.