intravenous anti-influenza drug oseltamivir will not induce torsade de pointes: evidences from proarrhythmia model and action-potential assay
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2016
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Abstract
We evaluated proarrhythmic risk of intravenous oseltamivir with chronic atrioventricular block canine model (n = 4) and action-potential assay on guinea-pig right ventricle (n = 5). Oseltamivir in doses of 3–30 mg/kg, i.v. did not induce torsade de pointes in the canine model, whereas that in concentrations of 30–300 μM decreased maximum rate of phase 0 depolarization, shortened action potential duration at 30%, 60% and 90% repolarization levels, but prolonged difference in action-potential duration between 30% and 90% repolarization levels in a concentration-related manner. These results indicate that oseltamivir will not induce torsade de pointes clinically, since it inhibits both inward and outward currents.
| Reference Key |
nakamura2016journalintravenous
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| Authors | ;Yuji Nakamura;Rieko Sasaki;Xin Cao;Takeshi Wada;Shogo Hamaguchi;Hiroko Izumi-Nakaseko;Kentaro Ando;Hikaru Tanaka;Akira Takahara;Atsushi Sugiyama |
| Journal | plant direct |
| Year | 2016 |
| DOI |
10.1016/j.jphs.2016.04.018
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