non-invasive in vivo imaging in small animal research

Clicks: 285
ID: 145042
2006
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Abstract
Non-invasive real time in vivo molecular imaging in small animal models has become the essential bridge between in vitro data and their translation into clinical applications. The tremendous development and technological progress, such as tumour modelling, monitoring of tumour growth and detection of metastasis, has facilitated translational drug development. This has added to our knowledge on carcinogenesis. The modalities that are commonly used include Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Positron Emission Tomography (PET), bioluminescence imaging, fluorescence imaging and multi-modality imaging systems. The ability to obtain multiple images longitudinally provides reliable information whilst reducing animal numbers. As yet there is no one modality that is ideal for all experimental studies. This review outlines the instrumentation available together with corresponding applications reported in the literature with particular emphasis on cancer research. Advantages and limitations to current imaging technology are discussed and the issues concerning small animal care during imaging are highlighted.
Reference Key
koo2006cellularnon-invasive Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;V. Koo;P. W. Hamilton;K. Williamson
Journal journal of the serbian chemical society
Year 2006
DOI
10.1155/2006/245619
URL
http://dx.doi.org/10.1155/2006/245619
Keywords
neoplasms Oncology including cancer and carcinogenscytology tumors

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