lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
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ID: 144540
2019
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Abstract
Innate T cells (ITC) contain many subsets and are poised to promptly respond to antigens and pathogens, but how this poised state is maintained is still unclear. Here the authors perform single-cell RNA-seq to align the various ITC subsets along an ‘innateness gradient’ that is associated with changes in proliferation and effector functions.
| Reference Key |
gutierrez-arcelus2019naturelymphocyte
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|---|---|
| Authors | ;Maria Gutierrez-Arcelus;Nikola Teslovich;Alex R. Mola;Rafael B. Polidoro;Aparna Nathan;Hyun Kim;Susan Hannes;Kamil Slowikowski;Gerald F. M. Watts;Ilya Korsunsky;Michael B. Brenner;Soumya Raychaudhuri;Patrick J. Brennan |
| Journal | educacao e sociedade |
| Year | 2019 |
| DOI |
10.1038/s41467-019-08604-4
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| URL | |
| Keywords |
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