human endogenous retroviruses as pathogenic factors in the development of schizophrenia

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ID: 144475
2016
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Abstract
Schizophrenia is a complex disorder, characterized by the interplay between genetic and environmental factors. Human endogenous retroviruses (HERVs), genetic elements that originated from infections by exogenous retroviruses millions of years ago, comprise ~8% of the human genome. Here, we provide a comprehensive review of accumulating evidence, detailing HERV aberrancies associated with schizophrenia. Studies examining the genome, transcriptome, and proteome of individuals with schizophrenia provide data that support the association of these viral elements with the disorder. Molecular differences can be found within the central nervous system (CNS) and peripheral tissues. However, additional studies are needed to substantiate the reported link and to address several discrepancies among previous investigations. We further discuss potentially relevant pathogenic mechanisms to the development of schizophrenia.
Reference Key
ehasler2016frontiershuman Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Gregor eHasler;Gorjan eSlokar
Journal journal of experimental psychology general
Year 2016
DOI
10.3389/fpsyt.2015.00183
URL
http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00183/full
Keywords
schizophrenia gene-environment interaction pathogenesis

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