An Essential Role of Hrs/Vps27 in Endosomal Cholesterol Trafficking

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ID: 14444
2012
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Abstract
The endosomal sorting complex required for transport (ESCRT) plays a crucial role in the degradation of ubiquitinated endosomal membrane proteins. Here, we report that Hrs, a key protein of the ESCRT-0 complex, is required for the transport of low-density lipoprotein-derived cholesterol from endosomes to the endoplasmic reticulum. This function of Hrs in cholesterol transport is distinct from its previously defined role in lysosomal sorting and downregulation of membrane receptors via the ESCRT pathway. In line with this, knocking down other ESCRT proteins does not cause prominent endosomal cholesterol accumulation. Importantly, the localization and biochemical properties of key cholesterol-sorting proteins, NPC1 and NPC2, appear to be unchanged upon Hrs knockdown. Our data identify Hrs as a regulator of endosomal cholesterol trafficking and provide additional insights into the budding of intralumenal vesicles.
Reference Key
du2012ancell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Du, Ximing;Kazim, Abdulla S.;Brown, Andrew J.;Yang, Hongyuan;
Journal Cell reports
Year 2012
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S2211124711000052
Keywords Keywords not found

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