Bioinspired peptides as versatile nucleic acid delivery platforms.

Clicks: 248
ID: 14397
2013
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Ranked #16 of 35 articles by views in Journal of controlled release : official journal of the Controlled Release Society

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Abstract
Non-viral gene therapy approaches have strongly established the utility of peptides as integral constituents of delivery platforms devised for efficient transfer of therapeutic molecules into cells. Among these, cell-penetrating peptides (CPPs), encompassing a family of short peptide sequences and their chimeric derivatives, have gained versatility through the addition of de novo peptide ligands primarily to facilitate cell-specific nucleic acid delivery in vitro and in vivo. The review illustrates the structural requirements of a noteworthy peptide TAT-PTD and other derivatives chiefly to exemplify their implication in gene therapy. An overview of the emerging concept and recent explorations will be presented through unique examples which form a facet in nanotechnology-based cancer therapy. Finally the basis for the utility of CPPs in plants will be discussed in view of its biotechnological potential.
Reference Key
gopal2013bioinspiredjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gopal, Vijaya;
Journal Journal of controlled release : official journal of the Controlled Release Society
Year 2013
DOI
10.1016/j.jconrel.2013.02.021
URL
Keywords Keywords not found

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