Bioinspired peptides as versatile nucleic acid delivery platforms.
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ID: 14397
2013
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Abstract
Non-viral gene therapy approaches have strongly established the utility of peptides as integral constituents of delivery platforms devised for efficient transfer of therapeutic molecules into cells. Among these, cell-penetrating peptides (CPPs), encompassing a family of short peptide sequences and their chimeric derivatives, have gained versatility through the addition of de novo peptide ligands primarily to facilitate cell-specific nucleic acid delivery in vitro and in vivo. The review illustrates the structural requirements of a noteworthy peptide TAT-PTD and other derivatives chiefly to exemplify their implication in gene therapy. An overview of the emerging concept and recent explorations will be presented through unique examples which form a facet in nanotechnology-based cancer therapy. Finally the basis for the utility of CPPs in plants will be discussed in view of its biotechnological potential.
| Reference Key |
gopal2013bioinspiredjournal
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|---|---|
| Authors | Gopal, Vijaya; |
| Journal | Journal of controlled release : official journal of the Controlled Release Society |
| Year | 2013 |
| DOI |
10.1016/j.jconrel.2013.02.021
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| URL | |
| Keywords | Keywords not found |
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