Chemoselective Tyrosine Bioconjugation through Sulfate Click Reaction.

Clicks: 253
ID: 14383
2018
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Ranked #56 of 117 articles by views in Chemistry (Weinheim an der Bergstrasse, Germany)

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Abstract
A novel and selective tyrosine functionalization strategy through SuFEx (sulfur fluoride exchange) chemistry is presented. In this approach, free tyrosine (Tyr) reacts selectively with aryl fluorosulfate in the presence of various nucleophilic amino acid residues in bio-tolerable conditions. Chemoselectivity of this unique SuFEx reaction was confirmed in amino acid, peptide, and protein conjugations. The functions of peptides and proteins were well-preserved as demonstrated from the Tyr-specific modification of cell-penetrating peptide and erythropoietin. This method is well-suited for residue-specific modification of native proteins, and thus would expand the versatility of bio-conjugation in protein chemistry.
Reference Key
choi2018chemoselectivechemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Choi, Eun Joung;Jung, Dongwook;Kim, Jong-Seo;Lee, Yan;Kim, B Moon;
Journal Chemistry (Weinheim an der Bergstrasse, Germany)
Year 2018
DOI
10.1002/chem.201802380
URL
Keywords Keywords not found

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