Design and biological characterization of novel cell-penetrating peptides preferentially targeting cell nuclei and subnuclear regions.

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ID: 14382
2018
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Abstract
Within this study, we report about the design and biological characterization of novel cell-penetrating peptides (CPPs) with selective suborganelle-targeting properties. The nuclear localization sequence N50, as well as the nucleoli-targeting sequence NrTP, respectively, were fused to a shortened version of the cell-penetrating peptide sC18. We examined cellular uptake, subcellular fate and cytotoxicity of these novel peptides, N50-sC18* and NrTP-sC18*, and found that they are nontoxic up to a concentration of 50 or 100 µM depending on the cell lines used. Moreover, detailed cellular uptake studies revealed that both peptides enter cells via energy-independent uptake, although endocytotic processes cannot completely excluded. However, initial drug delivery studies demonstrated the high versatility of these new peptides as efficient transport vectors targeting specifically nuclei and nucleoli. In future, they could be further explored as parts of newly created peptide-drug conjugates.
Reference Key
gronewold2018designbeilstein Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gronewold, Anja;Horn, Mareike;Neundorf, Ines;
Journal Beilstein journal of organic chemistry
Year 2018
DOI
10.3762/bjoc.14.116
URL
https://doi.org/10.3762/bjoc.14.116
Keywords Keywords not found

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