effect of left ventricular outflow tract obstruction on left atrial mechanics in hypertrophic cardiomyopathy

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ID: 143632
2015
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Abstract
Left atrial (LA) volumes are known to be increased in hypertrophic cardiomyopathy (HCM) and are a predictor of adverse outcome. In addition, LA function is impaired and is presumed to be due to left ventricular (LV) diastolic dysfunction as a result of hypertrophy and myocardial fibrosis. In the current study, we assess the incremental effect of outflow tract obstruction (and concomitant mitral regurgitation) on LA function as assessed by LA strain. Patients with HCM (50 obstructive, 50 nonobstructive) were compared to 50 normal controls. A subset of obstructive patients who had undergone septal myectomy was also studied. Utilising feature-tracking software applied to cardiovascular magnetic resonance images, LA volumes and functional parameters were calculated. LA volumes were significantly elevated and LA ejection fraction and strain were significantly reduced in patients with HCM compared with controls and were significantly more affected in patients with obstruction. LA volumes and function were significantly improved after septal myectomy. LVOT obstruction and mitral regurgitation appear to further impair LA mechanics. Septal myectomy results in a significant reduction in LA volumes, paralleled by an improvement in function.
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williams2015biomedeffect Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Lynne K. Williams;Raymond H. Chan;Shemy Carasso;Miranda Durand;Jimmy Misurka;Andrew M. Crean;Anthony Ralph-Edwards;Christiane Gruner;Anna Woo;John R. Lesser;Barry J. Maron;Martin S. Maron;Harry Rakowski
Journal spectrochimica acta - part a: molecular and biomolecular spectroscopy
Year 2015
DOI
10.1155/2015/481245
URL
http://dx.doi.org/10.1155/2015/481245
Keywords
Medicine

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