comparison of magnetic resonance imaging and serum biomarkers for detection of human pluripotent stem cell-derived teratomas
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ID: 143347
2016
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Abstract
The use of cells derived from pluripotent stem cells (PSCs) for regenerative therapies confers a considerable risk for neoplastic growth and teratoma formation. Preclinical and clinical assessment of such therapies will require suitable monitoring strategies to understand and mitigate these risks. Here we generated human-induced pluripotent stem cells (iPSCs), selected clones that continued to express reprogramming factors after differentiation into cardiomyocytes, and transplanted these cardiomyocytes into immunocompromised rat hearts post-myocardial infarction. We compared magnetic resonance imaging (MRI), cardiac ultrasound, and serum biomarkers for their ability to delineate teratoma formation and growth. MRI enabled the detection of teratomas with a volume >8 mm3. A combination of three plasma biomarkers (CEA, AFP, and HCG) was able to detect teratomas with a volume >17 mm3 and with a sensitivity of more than 87%. Based on our findings, a combination of serum biomarkers with MRI screening may offer the highest sensitivity for teratoma detection and tracking.
| Reference Key |
riegler2016stemcomparison
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| Authors | ;Johannes Riegler;Antje Ebert;Xulei Qin;Qi Shen;Mouer Wang;Mohamed Ameen;Kazuki Kodo;Sang-Ging Ong;Won Hee Lee;Grace Lee;Evgenios Neofytou;Joseph D. Gold;Andrew J. Connolly;Joseph C. Wu |
| Journal | nature reviews gastroenterology & hepatology |
| Year | 2016 |
| DOI |
10.1016/j.stemcr.2015.12.008
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