synthesis, chemical characterization and biological screening for cytotoxicity and antitumor activity of organotin (iv) derivatives of 3,4-methylenedioxy 6-nitrophenylpropenoic acid
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ID: 143340
2007
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Abstract
A series of mono-, di- and triorganotin compounds with general formulae [RSnL2Cl], R = Bu (compound 3), [R2SnL2], where R = Me, Et, Bu, Oct (compounds 1, 2, 4 and 6) and [R3SnL], where R = Bu, Cy and Ph (compounds 5, 7 and 8) and where L = 3,4-methylenedioxy-6-nitrophenylpropenoic acid have been prepared and characterized by elemental analysis, multinuclear (1H-, 13C- and 119Sn-) NMR and mass spectrometry. The ligand and its respective organotin complexes were screened for cytotoxicity using the brine shrimp lethality assay and for antitumor activity using the crown gall tumor inhibition (potato disc) assay. The bioassay results support the conclusion that the biological activities of these synthetic compounds are in the following order: [RSnL2Cl] < [R2SnL2] < [R3SnL].
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mirza2007moleculessynthesis,
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| Authors | ;Bushra Mirza;Saqib Ali;Muhammad Hanif;Mukhtiar Hussain;Muhammad Sheeraz Ahmad |
| Journal | Journal of ethnopharmacology |
| Year | 2007 |
| DOI |
10.3390/12102348
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