trypanosoma cruzi: identification of specific epimastigote antigens by human immune sera trypanosoma cruzi: identificação de antígenos específicos de epimastigotas reconhecidos por soros humanos imunes

Clicks: 345
ID: 143230
1989
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Abstract
Soluble antigens from epimastigotes of Trypanosoma cruzi were analyzed by western blot in terms of their reactivity with sera from patients with Chagas' disease. In addition, sera from patients with visceral (AVL) and tegumentar leishmaniasis (ATL) were also tested in order to identify cross-reactivities with Trypanosoma cruzy antigens. Twenty eight polypeptides with molecular weights ranging from 14 kDa to 113 kDa were identified with sera from Chagas' disease patients. An extensive cross-reactivity was observed when sera from human visceral leishmaniasis were used, while only a slight cross-reaction was observed with sera from tegumentar leishmaniasis. On the other hand, 10 polypeptidesspecifically reacting with sera from Chagas' disease patients were identified. Among them, the antigens with molecular weights of 46 kDa and 25 kDa reacted with all sera teste and may be good candidates for specific immunodiagnosis of Chagas' disease.
Antígenos solúveis de epimastigotas de Trypanosoma cruzi foram analisados por "imunoblot" a fim de verificar sua reatividade com soros de pacientes com doença de Chagas. Além disso, soro de pacientes com leishmaniose visceral (LVA) e tegumentar americana (LTA) foram também analisados com o objetivo de se identificar oa antígenos de reação cruzada com o Trypanosoma cruzi. Pelo menos 28 polipeptídeos, com pesos moleculares variando de 14 a 113 kDa foram identificados com soros de pacientes com doença de Chagas. Uma intensa reatividade cruzada foi observada quando foram utilizados soros de pacientes com leishmaniose visceral, enquanto que uma fraca reação cruzada foi observada com soros de pacientes portadores de leishmaniose tegumentar. Por outro lado, pelo menos 10 polipeptídeos puderam ser identificados apresentando reação específica com soros de pacientes chagásicos. Entre estes, os polipeptídeos de pesos moleculares de 46 kDa e 25 kDa que reagiram com todos esses soros e são potencialmente bons candidatos a antígenos específicos no diagnósticos sorológico da doença de Chagas.
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morgado1989memriastrypanosoma Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;M. G. Morgado;J. Ivo-dos-Santos;R. T. Pinho;E. Argüelles;J. M. Rezende;B. Galvão-Castro
Journal kurdistan journal of applied research
Year 1989
DOI
10.1590/S0074-02761989000300004
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761989000300004
Keywords
western blot trypanosoma cruzi antigens tropical medicinemicrobiology cross-reactivityarctic medicine

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