a microfluidic chip with double-slit arrays for enhanced capture of single cells

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ID: 143025
2018
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Abstract
The application of microfluidic technology to manipulate cells or biological particles is becoming one of the rapidly growing areas, and various microarray trapping devices have recently been designed for high throughput single-cell analysis and manipulation. In this paper, we design a double-slit microfluidic chip for hydrodynamic cell trapping at the single-cell level, which maintains a high capture ability. The geometric effects on flow behaviour are investigated in detail for optimizing chip architecture, including the flow velocity, the fluid pressure, and the equivalent stress of cells. Based on the geometrical parameters optimized, the double-slit chip enhances the capture of HeLa cells and the drug experiment verifies the feasibility of the drug delivery.
Reference Key
xu2018micromachinesa Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jingyi Xu;Shulei Chen;Dongyang Wang;Yue Jiang;Ming Hao;Guangyu Du;Dechun Ba;Qiao Lin;Qi Mei;Yingchao Ning;Da Su;Kun Liu
Journal chemistryopen
Year 2018
DOI
10.3390/mi9040157
URL
http://www.mdpi.com/2072-666X/9/4/157
Keywords
single cell neuromodulation sciatic nerve microfluidic chip precision medicinemechanical engineering and machinery

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