langerhans cell histiocytosis of skin: a clinicopathologic analysis of five cases

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ID: 142721
2006
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Ranked #60 of 318 articles by views in crystallization of organic compounds: an industrial perspective

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Abstract
Background and Aims: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of histiocytes characterized by a proliferation of abnormal and clonal Langerhans cells. We retrospectively studied clinicopathologic features of this disorder in five cases. Methods: Clinical and histopathological findings of five cases of cutaneous LCH were reviewed based on the hospital records. Results: The age of patients ranged from 28 days to 5 years and M: F ratio was 1:1.5. Clinically, the diagnoses suggested were histiocytosis, varicella, transient neonatal pustular melanosis, keloid, sarcoidosis, seborrheic keratosis and LCH. The most common type of skin lesion was a generalized papular lesion. Histologically, all cases showed aggregates of large mononuclear histiocytes (Langerhans cells) with reniform, irregular, cleaved nuclei and abundant eosinophilic cytoplasm. There was multi-systemic involvement in two patients and single-system involvement in three patients. Conclusion: Cutaneous lesions may be the sole presenting feature of LCH. Diagnosis is based on demonstration of S-100 positive histiocytes.
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Authors ;Punia Rajpal;Bagai Maneesh;Mohan Harsh;Thami G
Journal crystallization of organic compounds: an industrial perspective
Year 2006
DOI
DOI not found
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http://www.ijdvl.com/article.asp?issn=0378-6323;year=2006;volume=72;issue=3;spage=211;epage=214;aulast=Punia
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