culturing intestinal stem cells: applications for colorectal cancer research

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ID: 142665
2014
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Abstract
Recent advance of sequencing technology has revealed genetic alterations in colorectal cancer. The biological function of recurrently mutated genes has been intensively investigated through mouse genetic models and colorectal cancer cell lines. Although these experimental models may not fully reflect biological traits of human intestinal epithelium, they provided insights into the understanding of intestinal stem cell self-renewal, leading to the development of novel human intestinal organoid culture system. Intestinal organoid culture enabled to expand normal or tumor epithelial cells in vitro retaining their stem cell self-renewal and multiple differentiation. Gene manipulation of these cultured cells may provide an attractive tool for investigating genetic events involved in colorectal carcinogenesis.
Reference Key
efujii2014frontiersculturing Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Masayuki eFujii;Toshiro eSato
Journal chemical record (new york, ny)
Year 2014
DOI
10.3389/fgene.2014.00169
URL
http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00169/full
Keywords
niche organoids r-spondingenetics

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