neonatal acute megakaryoblastic leukemia presenting with leukemia cutis and multiple intracranial lesions successfully treated with unrelated cord blood transplantation
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ID: 142465
2015
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Abstract
Neonatal acute megakaryoblastic leukemia (AMKL) without Down syndrome (DS) is an extremely rare disorder. We report of a one-day-old male infant without DS who developed AMKL with leukemia cutis and right facial nerve palsy. Magnetic resonance imaging of the patient’s brain revealed multiple intracranial tumors. A biopsy specimen of the skin lesion was suggestive of AMKL, but the bone marrow leukemic cells were less than 5% of the marrow nucleated cells. The skin and intracranial lesions had spontaneously regressed within one and a half months, but the patient’s anemia and thrombocytopenia gradually worsened and the leukemic cells in the bone marrow gradually increased to more than 20% of the nucleated cells. In addition, multiple intracranial lesions reappeared at 72 days of life. We diagnosed the patient with AMKL, and chemotherapy followed by unrelated cord blood transplantation after a reduced-intensity conditioning regimen resulted in sustained complete remission. At present, the patient is well, and he has demonstrated normal development for five years.
| Reference Key |
tsujimoto2015caseneonatal
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|---|---|
| Authors | ;Hiroshi Tsujimoto;Shinji Kounami;Yasuyuki Mitani;Takashi Watanabe;Katsunari Takifuji |
| Journal | Turkish journal of haematology : official journal of Turkish Society of Haematology |
| Year | 2015 |
| DOI |
10.1155/2015/610581
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| URL | |
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