heterofucans from the brown seaweed canistrocarpus cervicornis with anticoagulant and antioxidant activities

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ID: 142451
2011
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Abstract
Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated L-fucose. We extracted six fucans from Canistrocarpus cervicornis by proteolytic digestion followed by sequential acetone precipitation. These heterofucans are composed mainly of fucose, glucuronic acid, galactose and sulfate. No polysaccharide was capable of prolonging prothrombin time (PT) at the concentration assayed. However, all polysaccharides prolonged activated partial thromboplastin time (aPTT). Four sulfated polysaccharides (CC-0.3/CC-0.5/CC-0.7/CC-1.0) doubled aPTT with only 0.1 mg/mL of plasma, only 1.25-fold less than Clexane®, a commercial low molecular weight heparin. Heterofucans exhibited total antioxidant capacity, low hydroxyl radical scavenging activity, good superoxide radical scavenging efficiency (except CC-1.0), and excellent ferrous chelating ability (except CC-0.3). These results clearly indicate the beneficial effect of C. cervicornis polysaccharides as anticoagulants and antioxidants. Further purification steps and additional studies on structural features as well as in vivo experiments are needed to test the viability of their use as therapeutic agents.
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rocha2011marineheterofucans Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Hugo Alexandre Oliveira Rocha;Sara Lima Cordeiro;Mariana Santana Santos Pereira Costa;Luciana Guimaraes Alves;Nednaldo Dantas-Santos;Gabriel Pereira Fidelis;Leonardo Thiago Duarte Barreto Nobre;Rafael Barros Gomes Camara;Leandro Silva Costa
Journal jixie gongcheng xuebao/journal of mechanical engineering
Year 2011
DOI
10.3390/md9010124
URL
http://www.mdpi.com/1660-3397/9/1/124/
Keywords
free radicals

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