beta-human chorionic gonadotropin and uterine artery doppler measurements for the prediction of success of single dose methotrexate treatment in tubal ectopic pregnancies

Clicks: 466
ID: 142450
2016
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Abstract
Objectives: To evaluate the impact of the uterine artery Doppler values and the change of β-Human chorionic gonadotropin (β-HCG) levels from day 0 to day 4 for prediction of the success of single dose methotrexate treatment in tubal pregnancy cases. Study Design: 50 patients with tubal pregnancy were included the prospective study. The location and size of ectopic pregnancy, bilateral uterine artery pulsed color doppler imaging was examined by ultrasonography and serum β-HCG levels were measured on day 0, 4, 7 of treatment. Success was defined as decrease of β-HCG level <10 mIU/mL with single dose methotrexate treatment. Multiple dose methotrexate treatment and surgical treatment were considered as treatment failure. Results: 32 patients (64%) treated with single dose methotrexate, 14 patients (28%) treated with multiple dose methotrexate, and 4 patients (8%) treated with surgery. In the group with β-HCG level decrease > 15.04% on day 4, single-dose methotrexate therapy were 3.82 times more successful than the group without > 15.04% β-HCG decrease. However, no significant alteration of uterine artery Doppler measurements was determined on the same days. Conclusion: Reduction rate in the β-HCG level on day 4 of treatment can be used in determination the success of single-dose methotrexate therapy.
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Authors ;Kılıç Çiğdem;Mehmet Metin Altay;Tuğba Kınay;Metin Kaplan;Serap Fırtına Tuncer;Enis Özkaya;Ahmet Okyar Erol;Orhan Gelişen
Journal journal of veterinary research
Year 2016
DOI
10.21613/GORM.2016.90
URL
http://gorm.com.tr/index.php/GORM/article/view/90
Keywords
β-human chorionic gonadotropin methotrexate

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