trisomy of chromosome 8 in ph-negative cells of the bone marrow in patients with chronic myeloid leukemia treated with inhibitors of bcr-abl tyrosinkinases

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ID: 142131
2009
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Abstract
Aim. To analyse clinical implications of chromosome 8 trisomy in Ph-negative cells of the bone marrow in patients with chronic myeloid leukemia (CML) treated with inhibitors of tyrosinkinases (ITK). Material and methods. A total of 386 patients with CML (chronic phase - 288, acceleration phase - 77) received imatinib (400-800 mg/day). Because of resistance and/or intolerance some patients were switched to ITK II (nilotinib, dasatinib, bozutinib). This study included 8 CML patients (7 in a chronic phase, 1 in acceleration phase) treated with BCR-ABL ITK inhibitors of the first (imatinib) and the second line (ITK-II). The standard cytogenetic examination, on demand - investigation of the interphase nuclei with FISH, in some cases morphological, cytochemical and histological examinations of the bone marrow were made. Results. The existence of a Ph-negative clone with trisomy of chromosome 8 had no negative effect on the course of the disease. The patients showed a stable hematological and cytogenetic response and no need in changing treatment policy. In long-term follow-up Ph-negative clone with trisomy of the chromosome 8 persisted without a clear trend to rise in most patients. Conclusion. Detection of a Ph-negative clone with chromosome 8 trisomy at early stages suggests parallel existence of Ph-positive and Ph-negative clones. None of the patients had myelodisplasia.
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Authors ;Anna Grigor'evna Turkina;Elena Vasil'evna Domracheva;Aleksandra Valer'evna Vorontsova;Elena Aleksandrovna Aseeva;Ol'ga Yur'evna Vinogradova;Ol'ga Veniaminovna Stakhina;Galina Anatol'evna Gusarova;Ol'ga Arkad'evna Dyagileva;Elena Aleksandrovna Semenova;Marina Vasil'evna Vakhrusheva;Tamara Ivanovna Kolosheynova;Evgeniy Mikhaylovich Abakumov;Ekaterina Yur'evna Chelysheva;Svetlana Rudol'fovna Goryacheva;Tat'yana Vladimirovna Ivanova;Elena Stanislavovna Zakharova;Lyubov' Yur'evna Kolosova;Adel' Vladimirovna Zakharova;Irina Nikolaevna Naumova;Larisa Vladimirovna Dyachenko;Sergey Mikhaylovich Kulikov;Lidiya Grigor'evna Kovaleva;Nina Dmitrievna Khoroshko;A G Turkina;E V Domracheva;A V Vorontsova;E A Aseeva;O Yu Vinogradova;O V Stakhina;G A Gusarova;O A Dyagileva;E A Semenova;M V Vakhrusheva;T I Kolosheinova;E M Abakumov;E Yu Chelysheva;S R Goryacheva;T V Ivanova;E S Zakharova;L Yu Kolosova;A V Zakharova;I N Naumova;L V Dyachenko;S M Kulikov;L G Kovaleva;N D Khoroshko
Journal indian journal of chemical technology
Year 2009
DOI
DOI not found
URL
https://ter-arkhiv.ru/0040-3660/article/view/30364
Keywords
chronic myeloid leukemia

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