one-pot gold-catalyzed synthesis of 3-silylethynyl indoles from unprotected o-alkynylanilines

Clicks: 286
ID: 141329
2011
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Abstract
The Au(III)-catalyzed cyclization of 2-alkynylanilines was combined in a one-pot procedure with the Au(I)-catalyzed C3-selective direct alkynylation of indoles using the benziodoxolone reagent TIPS-EBX to give a mild, easy and straightforward entry to 2-substituted-3-alkynylindoles. The reaction can be applied to unprotected anilines, was tolerant to functional groups and easy to carry out (RT, and requires neither an inert atmosphere nor special solvents).
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brand2011beilsteinone-pot Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jonathan P. Brand;Clara Chevalley;Jérôme Waser
Journal Molecular autism
Year 2011
DOI
10.3762/bjoc.7.65
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