High-glucose/high-cholesterol diet in zebrafish evokes diabetic and affective pathogenesis: The role of peripheral and central inflammation, microglia and apoptosis.

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ID: 14132
2019
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Ranked #2 of 133 articles by views in progress in neuro-psychopharmacology & biological psychiatry

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Abstract
Neuroinflammation and metabolic deficits contribute to the etiology of human affective disorders, such as anxiety and depression. The zebrafish (Danio rerio) has recently emerged as a powerful new model organism in CNS disease modeling. Here, we exposed zebrafish to 2% glucose and 10% cholesterol for 19 days to experimentally induce type 2 diabetes (DM) and to assess stress responses, microglia, inflammation and apoptosis. We analyzed zebrafish behavior in the novel tank and light-dark box (Days 15-16) tests, as well as biochemical and genomic biomarkers (Day 19). Confirming DM-like state in zebrafish, we found higher whole-body glucose, triglyceride, total cholesterol, low-density lipoprotein levels and glucagon mRNA expression, and lower high-density lipoprotein levels. DM zebrafish also showed anxiety-like behavior, elevated whole-body cortisol and cytokines IFN-γ and IL-4, as well as higher brain mRNA expression of the glucocorticoid receptor, CD11b (a microglial biomarker), pro-inflammatory cytokines IL-6, IL-6R and TNF-α (but not IL-1β or anti-inflammatory cytokines IL-4 and IL-10), GFAP (an astrocyte biomarker), neurotrophin BDNF, its receptor p75 (but not TrkB), as well as apoptotic Bax and Caspase-3 (but not BCl-2) genes. Collectively, this supports the overlapping nature of DM-related affective pathogenesis and emphasizes the role of peripheral and central inflammation and apoptosis in DM-related affective and neuroendocrine deficits in zebrafish.
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wang2019highglucosehighcholesterolprogress Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors JiaJia Wang, YanJun Li, Ke Lai, QiMei Zhong, Konstantin A Demin, Allan V Kalueff, Cai Song
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Journal progress in neuro-psychopharmacology & biological psychiatry
Year 2019
DOI
S0278-5846(19)30348-3
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