autophagy and urothelial carcinoma of the bladder: a review
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ID: 141079
2016
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Abstract
The incidence of urothelial carcinoma of the urinary bladder (bladder cancer) remains high. While other solid organ malignancies
have seen significant improvement in morbidity and mortality, there has been little change in bladder cancer mortality in the
past few decades. The mortality is mainly driven by muscle invasive bladder cancer, but the cancer burden remains high even in
nonmuscle invasive bladder cancer due to high recurrence rates and risk of progression. While apoptosis deregulation has long
been an established pathway for cancer progression, nonapoptotic pathways have gained prominence of late. Recent research in
the role of autophagy in other malignancies, including its role in treatment resistance, has led to greater interest in the role of autophagy
in bladder cancer. Herein, we summarize the literature regarding the role of autophagy in bladder cancer progression and
treatment resistance. We address it by systematically reviewing treatment modalities for nonmuscle invasive and muscle invasive
bladder cancer.
| Reference Key |
chandrasekar2016investigativeautophagy
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|---|---|
| Authors | ;Thenappan Chandrasekar;Christopher P. Evans |
| Journal | ciência rural |
| Year | 2016 |
| DOI |
10.4111/icu.2016.57.S1.S89
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| URL | |
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