pemphigus herpetiformis - a case report of a rare form of pemphigus and review of the literature
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ID: 140776
2016
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Abstract
Introduction. Pemphigus herpetiformis is the rare variant of pemphigus with
characteristic clinical features, histopathological findings different from
the convectional pemphigus, and immunological findings consistent with
pemphigus. Case report. We presented a 65-year-old woman with initial
pruritus followed by pruritic urticarial papules and plaques, some with
annular rings of tense vesicles on the periphery, on the trunk and
extremities, with no mucous lesions. Histopathological examination
demonstrated spongiosis and intraepidermal vesicles in the mid or subcorneal
epidermis in some biopsy specimen, with neutrophil and eosinophil
infiltrate. Direct immunoflorescent microscopy revealed intercellular IgG
deposition, most prominent in the upper layers of epidermis. Indirect
immunoflorescent microscopy showed intercellular binding of IgG
autoantibodies in the patient’s sera. Initially the patient was threated
with systemic corticosteroids and azathioprine, but dapson provided complete
clinical remission. Conclusion. This entity was established 40 years ago,
and around 100 patients have been reported worldwide. It is important to be
aware of this particular form of pemphigus because clinical presentation,
course of the disease and therapeutic approach are different from
conventional forms of pemphigus.
| Reference Key |
jelena2016vojnosanitetskipemphigus
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|---|---|
| Authors | ;Stojković-Filipović Jelena;Lekić Branislav;Milčić Danijela;Milinković Mirjana V. |
| Journal | applied nursing research : anr |
| Year | 2016 |
| DOI |
10.2298/VSP150617044S
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| URL | |
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