thiol/disulfide status regulates the activity of thiol-containing kinases related to energy homeostasis in rat kidney
Clicks: 246
ID: 140515
2017
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
30.0
/100
246 views
29 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #40 of 122 articles by views in hypertension (dallas, tex : 1979)
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 122 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
ABSTRACT Considering that thiol-containing enzymes like kinases are critical for several metabolic pathways and energy homeostasis, we investigated the effects of cystine dimethyl ester and/or cysteamine administration on kinases crucial for energy metabolism in the kidney of Wistar rats. Animals were injected twice a day with 1.6 µmol/g body weight cystine dimethyl ester and/or 0.26 µmol/g body weight cysteamine from the 16th to the 20th postpartum day and euthanized after 12 hours. Pyruvate kinase, adenylate kinase, creatine kinase activities and thiol/disulfide ratio were determined. Cystine dimethyl ester administration reduced thiol/disulfide ratio and inhibited the kinases activities. Cysteamine administration increased the thiol/disulfide ratio and co-administration with cystine dimethyl ester prevented the inhibition of the enzymes. Regression between the thiol/disulfide ratio, and the kinases activities were significant. These results suggest that redox status may regulate energy metabolism in the rat kidney. If thiol-containing enzymes inhibition and oxidative stress occur in patients with cystinosis, it is possible that lysosomal cystine depletion may not be the only beneficial effect of cysteamine administration, but also its antioxidant and thiol-protector effect.
| Reference Key |
rech2017anaisthiol/disulfide
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;VIRGINIA C. RECH;NATHANA J. MEZZOMO;GENARO A. ATHAYDES;LUCIANE R. FEKSA;VANDRÉ C. FIGUEIREDO;ADRIANA KESSLER;ITIANE D. DE FRANCESCHI;CLOVIS M.D. WANNMACHER |
| Journal | hypertension (dallas, tex : 1979) |
| Year | 2017 |
| DOI |
10.1590/0001-3765201720160348
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.