efektivitas ekstrak bawang putih terhadap efek hepatotoksik aflatoksin b1 pada ayam pedaging periode awal

The aim of this study was to evaluate the effect of garlic extract (GE) in rations on the bloodcholesterol profiles of aflatoxin B-induced hepatotoxic in the early stage of broiler chickens. As many as140 one-day old chicks were used in this study. They were randomly divided into 16 treatment groups andeach group consists of 9 chickens. The experimental design adopted in this study was completely randomizedfactorial design consisting 4 concentrations of aflatoxin (A0 : 0 ppb, A1:500 ppb, A2: 1000 ppb and A3:1500 ppb) and 4 concentrations of garlic extract (B0: 0% B1:2% B2: 4% and B3 6%). The treatment wascarried out for 21 days. The serum levels of total cholesterol, low density lipoprotein (LDL) and highdensity lipoprotein (HDL), and HDL/LDL ratio were the examined. The result showed that Aflatoxin Bcaused hepatotoxicosis in broiler chickens indicated by the increase of total cholesterol and LDL, and thedecrease of HDL and HDL-LDL ratio. Treatment of chickens with 2% GE decreased total cholesterol andLDL level in serum, and increased HDL level and HDL-LDL ratio. No interaction effect was observedbetween aflatoxin B and GE extract treatments. It is evident that treatment of Garlic extract reduces thehepatotoxicosis effect of aflatoxin B treatment in broiler chickens.