remodeling of cardiovascular system and development of chronic kidney disease in patients with metabolic syndrome and obesity: role of genes enos, subunit p22-phox of nadph-oxidase and mthfr

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ID: 140191
2012
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Abstract
Aim. To examine contribution of polymorphisms of genes of endothelial NO-synthase (eNOS), NADPH-oxidase and methylenetetrahydrofolate reductase (mTHFR) to development of remodeling of cardiovascular system and chronic disease of the kidneys (CDK) in patients with metabolic syndrome (mS) and obesity. Material and methods. Standard clinical and device examinations were made and polymorphisms C242T of gene of subunit p22-phox of NADPH-oxidase, G894T of gene of eNOS and C677T of gene of MTHFR were studied in 66 MS patients (49 males and 17 females, age 19-62 years. Results. The presence of even one prognostically poor allele variants of the genes studied was registered in 83 examinees. The genotype 242TT p22-phox of NADPH-oxidase subunit was associated with the highest insulin resistance, allele 894T of gene eNOS - with reduced glomerular filtration rate and progression of left ventricular hypertrophy. Conclusion. Polymorphism of the genes the products of which modulate endothelial function can be considered as potential predictors of severity of MS target organs impairment.
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saginova2012remodeling Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;E A Saginova;M G Gallyamov;A V Balatsky;A V Kolotvin;M V Severova;L M Samokhodskaya;V V Fomin;T N Krasnova;N A Mukhin
Journal indian journal of chemical technology
Year 2012
DOI
DOI not found
URL
https://ter-arkhiv.ru/0040-3660/article/view/31037
Keywords
obesity metabolic syndrome chronic kidney disease left ventricular hypertrophy

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