impact of pdgf‐bb on cellular distribution and extracellular matrix in the healing rabbit achilles tendon three weeks post‐operation

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ID: 140188
2020
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Abstract
Current methods for tendon rupture repair suffer from two main drawbacks: insufficient strength and adhesion formation, which lead to rerupture and impaired gliding. A novel polymer tube may help to overcome these problems by allowing growth factor delivery to the wound site and adhesion reduction, and by acting as a physical barrier to the surrounding tissue. In this study, we used a bilayered DegraPol® tube to deliver PDGF‐BB to the wound site in a full‐transection rabbit Achilles tendon model. We then performed histological and immunohistochemical analysis at 3 weeks postoperation. Sustained delivery of PDGF‐BB to the healing Achilles tendon led to a significantly more homogenous cell distribution within the healing tissue. Lower cell densities next to the implant material were determined for +PDGF‐BB samples compared to −PDGF‐BB. PDGF‐BB application increased proteoglycan content and reduced alpha‐SMA+ areas, clusters of different sizes, mainly vessels. Finally, PDGF‐BB reduced collagens I and III in the extracellular matrix. The sustained delivery of PDGF‐BB via an electrospun DegraPol® tube accelerated tendon wound healing by causing a more uniform cell distribution with higher proteoglycan content and less fibrotic tissue. Moreover, the application of this growth factor reduced collagen III and alpha‐SMA, indicating a faster and less fibrotic tendon healing.
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brgisser2020febsimpact Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gabriella Meier Bürgisser, Olivera Evrova, Maurizio Calcagni, Chiara Scalera, Pietro Giovanoli, Johanna Buschmann
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Journal journal of ayub medical college, abbottabad : jamc
Year 2020
DOI
10.1002/2211-5463.12736
URL
https://doi.org/10.1002/2211-5463.12736
Keywords
collagen

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