plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation

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ID: 140182
1996
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Abstract
Leukocytosis and thrombocytopenia occur during cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC). Elevated circulating concentrations of macrophage colony-stimulating factor (M-CSF) are reported during thrombocytopenia and leukopenia of different origins. We have assessed M-CSF concentrations in 40 patients undergoing CPB with ECC. Plasma M-CSF concentrations were stable during ECC and increased at the 6th (7.3 ± 0.7 IU/μg protein) and 24th (8.6 ± 0.8 IU/μg protein) postoperative hour compared with pre-ECC values (4.9 ± 0.5 IU/μg protein). A deep thrombocytopenia was found during ECC and until the 24th postoperative hour. A drop of leukocyte counts was found during ECC followed by an increase after ECC weaning. While no correlation was found between M-CSF concentrations and the leukocyte counts, M-CSF values were positively correlated with platelet counts only before and during ECC. Thus, M-CSF is not implicated in the thrombocytopenia and the leukopenia generated during CPB with ECC. However the elevated levels of M-CSFa few hours after the end of ECC might play a role in the inflammatory process often observed after CPB.
Reference Key
denizot1996mediatorsplasma Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Y. Denizot, P. Fixe, E. Cornu, N. Nathan
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Journal polyhedron
Year 1996
DOI
10.1155/S0962935196000518
URL
http://dx.doi.org/10.1155/S0962935196000518
Keywords
pathology

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