severe case of thrombotic microangiopathy with a delayed diagnosis of atypical haemolytic uraemic syndrome successfully managed with eculizumab

Clicks: 188
ID: 139968
2015
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Abstract
Objectives: To describe the diagnosis and treatment of a severely ill patient presenting with thrombotic microangiopathy (TMA) of unknown cause. Case presentation: An adult female presented to intensive care with abdominal pain and haemorrhagic shock, requiring reanimation. Results: Features of TMA were present, but initial plasma exchange was ineffective. Treatment with the anti-C5 antibody, eculizumab, improved laboratory parameters and organ function, albeit slowly. Eculizumab remains effective and well tolerated after 30 months of treatment. Conclusion: This case demonstrates the complexities and importance of early identification of atypical haemolytic uraemic syndrome in patients presenting with TMA.
Reference Key
aresmouk2015europeansevere Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Duaa Aresmouk
Journal indian journal of dental research
Year 2015
DOI
10.12890/2015_000180
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