type i interferon induced and antagonized by foot-and-mouth disease virus

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ID: 139963
2018
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Ranked #259 of 875 articles by views in journal of magnetic resonance (san diego, calif : 1997)

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Abstract
Viral infections trigger the innate immune system, serving as the first line of defense, and are characterized by the production of type I interferon (IFN). Type I IFN is expressed in a broad spectrum of cells and tissues in the host and includes various subtypes (IFN-α, IFN-β, IFN-δ, IFN-ε, IFN-κ, IFN-τ, IFN-ω, IFN-ν, and IFN-ζ). Since the discovery of type I IFN, our knowledge of the biology of type I IFN has accumulated immensely, and we now have a substantial amount of information on the molecular mechanisms of the response and induction of type I IFN, as well as the strategies utilized by viruses to evade the type I IFN response. Foot-and-mouth disease virus (FMDV) can selectively alter cellular pathways to promote viral replication and evade antiviral immune activation of type I IFN. RNA molecules generated by FMDV are sensed by the cellular receptor for pathogen-associated molecular patterns (PAMPs). FMDV preferentially activates different sensor molecules and various signal transduction pathways. Based on knowledge of the virus or RNA pathogen specificity as well as the function-structure relationship of RNA sensing, it is necessary to summarize numerous signaling adaptors that are reported to participate in the regulation of IFN gene activation.
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Authors ;Xiao-xia Ma;Li-na Ma;Qiu-yan Chang;Peng Ma;Lin-Jie Li;Yue-ying Wang;Zhong-ren Ma;Xin Cao;Xin Cao
Journal journal of magnetic resonance (san diego, calif : 1997)
Year 2018
DOI
10.3389/fmicb.2018.01862
URL
https://www.frontiersin.org/article/10.3389/fmicb.2018.01862/full
Keywords
type i interferon picornaviridae rig-i mda5microbiology

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