evaluation of the immune response to cra and fra recombinant antigens of trypanosoma cruzi in c57bl/6 mice avaliação da resposta imune em camundongos c57bl/6 imunizados com os antígenos recombinantes cra e fra de trypanosoma cruzi

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ID: 139679
2003
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Abstract
Humoral and cellular immune responses were evaluated in 44 C57BL/6 mice immunized with the Trypanosoma cruzi recombinant antigens CRA and FRA. Both antigens induced cutaneous immediate-type hypersensitivity response. The levels of IgG1, IgG2a, IgG2b and IgG3 were high in CRA immunized mice. IgG3 was the predominant isotype. Although no difference in antibody levels was observed in FRA-immunized mice when compared to control mice, both antigens were able to induce lymphoproliferation in immunized mice. Significant differences were observed between incorporation of [³H]- thymidine by spleen cell stimulated in vitro with CRA or FRA and the control group. These results suggest that CRA and FRA could be involved in mechanisms of resistance to Trypanosoma cruzi infection.
As respostas imune humoral e celular foram avaliadas em 44 camundongos C57Bl/6 imunizados com os antígenos recombinantes CRA e FRA de Trypanosoma cruzi. Ambos antígenos induziram reação de hipersensibilidade do tipo imediato. Os níveis de IgG1, IgG2a, IgG2b e IgG3 foram elevados nos camundongos imunizados com CRA. IgG3 foi o isotipo predominante. Nenhuma diferença nos níveis de anticorpos foi observada em camundongos imunizados com FRA em relação aos animais controle. No entanto, ambos antígenos foram capazes de induzir proliferação de linfócitos em camundongos imunizados. Diferenças significativas foram observadas entre a incorporação da timidina - [³H] pelas células esplênicas estimuladas com CRA ou FRA e o grupo controle. Esses resultados sugerem que CRA e FRA poderão estar envolvidos nos mecanismos de resistência à infecção pelo Trypanosoma cruzi.
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Authors ;Valéria Rêgo Alves Pereira;Virginia Maria Barros de Lorena;Mineo Nakazawa;Ana Paula Galvão da Silva;Ulisses Montarroyos;Rodrigo Correa-Oliveira;Yara de Miranda Gomes
Journal mobile information systems
Year 2003
DOI
10.1590/S0037-86822003000400001
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000400001
Keywords
immunization trypanosoma cruzi tropical medicine lymphoproliferationarctic medicine

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