memantine effects on liver and adrenal gland of rats exposed to cold stress
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Abstract
Abstract
Background
Memantine attenuates heart stress due cold stress, however, no study focused its effects on liver and adrenal gland. We evaluated its effects on lipid depletion in adrenal gland and glycogen depletion in liver of rats exposed to cold stress.
Methods
Male rats divided into 4 groups: 1)Control (CON); 2)Memantine (MEM); 3)Induced cold stress (IH) and; 4)Induced cold stress memantine (IHF). Memantine were administrated by gavage (20 mg/kg/day) during eight days. Cold stress were performed during 4 hours once at - 8°C. Lipid and glycogen depletion were presented as its intensity levels.
Results
Rats exposed to cold stress presented the highest glycogen (p < 0.001) and lipid depletion (p < 0.001) in liver and adrenal gland, respectively. We noted that memantine significantly reduced lipid depletion in adrenal gland and glycogen depletion in liver.
Conclusion
Memantine prevented glycogen depletion in liver and lipid depletion in adrenal gland of rats under a cold stress condition.
| Reference Key |
marcelo2011internationalmemantine
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| Authors | ;Ferreira Marcelo;Valenti Vitor E;Cisternas Jose R;Ferreira Celso;Meneghini Adriano;Filho Celso;Breda João R;Correa João A;de Mello Monteiro Carlos;Junior Hugo;Murad Neif;de Abreu Luiz |
| Journal | journal of central south university of technology (english edition) |
| Year | 2011 |
| DOI |
10.1186/1755-7682-4-5
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| URL | |
| Keywords |
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