activation of eosinophils by lipopolysaccharide-induced monocyte-derived cytokines

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ID: 139288
2009
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Abstract
Background: : Interactions between eosinophils and monocytes after lipopolysaccharide inhalation are yet to be investigated. The mechanism of eosinophil activation induced by lipopolysaccharide in the presence of monocytes was investigated. Methods: : Expression of ICAM-1 and Mac-1 on eosinophils was evaluated after lipopolysaccharide stimulation in the presence of monocytes or monocyte culture supernatants. Cytokines in the supernatant of lipopolysaccharide-stimulated monocytes were measured using a cytokine array. Results: : Expression of ICAM-1 and Mac-1 on eosinophils was up-regulated after lipopolysaccharide stimulation in the presence of monocytes or monocyte culture supernatant. Lipopolysaccharide induced secretion of ENA-78, GMCSF, GRO, IL-1beta, IL-6, IL-10, MCP-1, TNF-alpha and MIP-3 alpha from monocytes. The up-regulation of ICAM-1, but not Mac-1, on eosinophils was attenuated by anti-TNF-alpha neutralizing antibody. Conclusions: : Monocyte-derived TNF-alpha plays an important role in the up-regulation of ICAM-I on eosinophils induced by lipopolysaccharides.
Reference Key
kobayashi2009allergologyactivation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Noriko Kobayashi, Hiroyuki Kayaba, Masahide Takeda, Kazutoshi Yamaguchi, Takahito Chiba, Wataru Ito, Junichi Chihara
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Journal current drug discovery technologies
Year 2009
DOI
10.2332/allergolint.O-07-527
URL
http://www.sciencedirect.com/science/article/pii/S1323893015306687
Keywords
allergy eosinophils lipopolysaccharide (lps) allergy

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