activation of eosinophils by lipopolysaccharide-induced monocyte-derived cytokines

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ID: 139288
2009
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Abstract
Background: : Interactions between eosinophils and monocytes after lipopolysaccharide inhalation are yet to be investigated. The mechanism of eosinophil activation induced by lipopolysaccharide in the presence of monocytes was investigated. Methods: : Expression of ICAM-1 and Mac-1 on eosinophils was evaluated after lipopolysaccharide stimulation in the presence of monocytes or monocyte culture supernatants. Cytokines in the supernatant of lipopolysaccharide-stimulated monocytes were measured using a cytokine array. Results: : Expression of ICAM-1 and Mac-1 on eosinophils was up-regulated after lipopolysaccharide stimulation in the presence of monocytes or monocyte culture supernatant. Lipopolysaccharide induced secretion of ENA-78, GMCSF, GRO, IL-1beta, IL-6, IL-10, MCP-1, TNF-alpha and MIP-3 alpha from monocytes. The up-regulation of ICAM-1, but not Mac-1, on eosinophils was attenuated by anti-TNF-alpha neutralizing antibody. Conclusions: : Monocyte-derived TNF-alpha plays an important role in the up-regulation of ICAM-I on eosinophils induced by lipopolysaccharides.
Reference Key
kobayashi2009allergologyactivation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Noriko Kobayashi;Hiroyuki Kayaba;Masahide Takeda;Kazutoshi Yamaguchi;Takahito Chiba;Wataru Ito;Junichi Chihara
Journal current drug discovery technologies
Year 2009
DOI
10.2332/allergolint.O-07-527
URL
http://www.sciencedirect.com/science/article/pii/S1323893015306687
Keywords
allergy eosinophils lipopolysaccharide (lps) allergy

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