leveraging ethnic group incidence variation to investigate genetic susceptibility to glioma: a novel candidate snp approach

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ID: 139278
2012
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Abstract
Objectives: Using a novel candidate SNP approach, we aimed to identify a possible genetic basis for the higher glioma incidence in Whites relative to East Asians and African-Americans. Methods: We hypothesized that genetic regions containing SNPs with extreme differences in allele frequencies across ethnicities are most likely to harbor susceptibility variants. We used International HapMap Project data to identify 3,961 candidate SNPs with the largest allele frequency differences in Whites compared to East Asians and Africans and tested these SNPs for association with glioma risk in a set of White cases and controls. Top SNPs identified in the discovery dataset were tested for association with glioma in five independent replication datasets. Results: No SNP achieved statistical significance in either the discovery or replication datasets after accounting for multiple testing. However, the most strongly associated SNP, rs879471, was found to be in linkage disequilibrium with a previously identified risk SNP, rs6010620, in RTEL1. We estimate rs6010620 to account for a glioma incidence rate ratio of 1.34 for Whites relative to East Asians. Conclusions: We explored genetic susceptibility to glioma using a novel candidate SNP method which may be applicable to other diseases with appropriate epidemiologic patterns.
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jacobs2012frontiersleveraging Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Daniel Ian Jacobs;Kyle M. Walsh;Margaret eWrensch;John eWiencke;Robert eJenkins;Richard eHoulston;Melissa eBondy;Matthias eSimon;Marc eSanson;Konstantinos eGousias;Johannes eSchramm;Marianne eLabussiere;Anna Luisa eDi Stefano;H-Erich eWichmann;Martina eMüller-Nurasyid;Stefan eSchreiber;Andre eFranke;Susanne eMoebus;Lewin eEisele;Andrew eDeWan;Robert eDubrow
Journal chemical record (new york, ny)
Year 2012
DOI
10.3389/fgene.2012.00203
URL
http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00203/full
Keywords
glioma ethnicity race admixture

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