attenuation of nad[p]h:quinone oxidoreductase 1 aggravates prostate cancer and tumor cell plasticity through enhanced tgfβ signaling
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2020
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Abstract
Thapa et al find that depletion of the antioxidant enzyme NAD[P]H:Quinone Oxidoreductase 1 (NQO1) accelerates prostate tumorigenesis and induces the epithelial-to-mesenchymal transition by activating TGFβ signaling. They also find that low NQO1 is associated with mesenchymal signature and biochemical recurrence in clinical samples.
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| Authors | ;Dinesh Thapa;Shih-Bo Huang;Amanda R. Muñoz;Xiaoyu Yang;Roble G. Bedolla;Chia-Nung Hung;Chun-Liang Chen;Tim H.-M. Huang;Michael A. Liss;Robert L. Reddick;Hiroshi Miyamoto;Addanki P. Kumar;Rita Ghosh |
| Journal | biotechnology & biotechnological equipment |
| Year | 2020 |
| DOI |
10.1038/s42003-019-0720-z
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