renal transplantation across abo barrier

Clicks: 350
ID: 139251
2013
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Abstract
In India, patients without a compatible blood group donor are usually excluded from renal transplantation. For young patients, it is a difficult therapeutic choice to stay on long-term dialysis. We describe the case of a 19-year-old male patient who had blood group O +ve and had no compatible donor in the family. His mother was B +ve and was willing to donate. The patient had an initial anti-B antibody titer of 1:512 and underwent antibody depletion with plasmapheresis (11 sessions) and intravenous immunoglobulin (IVIG) 100 mg/kg after every plasmapheresis. He also received rituximab 500 mg for 3 days prior to transplant and was induced with basiliximab. At the time of transplant, his anti-B titers were <1:8. Post-operatively, he required four sessions of plasmapheresis and IVIG as his titers rebounded to 1:64. The titers then spontaneously subsided to <1:16 and have stayed at the same level for 6 months post-transplant. The patient continues to have normal renal function with a creatinine of 1.4 mg/dl% and has had no episodes of rejection.
Reference Key
gupta2013indianrenal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;P N Gupta;S Pokhariyal;S Bansal;S Jain;V Saxena;R Sharma;M Jain;P Jha;S K Sethi;P Ghosh;A Tewari;R Ahlawat;V Kher
Journal journal of the chemical society - perkin transactions 1
Year 2013
DOI
10.4103/0971-4065.111857
URL
http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2013;volume=23;issue=3;spage=214;epage=216;aulast=Gupta
Keywords
chronic kidney disease urology

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