targeting hypoxia inducible factors-1α as a novel therapy in fibrosis

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ID: 138491
2017
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Abstract
Fibrosis, characterized by increased extracellular matrix (ECM) deposition, and widespread vasculopathy, has the prominent trait of chronic hypoxia. Hypoxia inducible factors-1α (HIF-1α), a key transcriptional factor in response to this chronic hypoxia, is involved in fibrotic disease, such as Systemic sclerosis (SSc). The implicated function of HIF-1α in fibrosis include stimulation of excessive ECM, vascular remodeling, and futile angiogenesis with further exacerbation of chronic hypoxia and deteriorate pathofibrogenesis. This review will focus on the molecular biological behavior of HIF-1α in regulating progressive fibrosis. Better understanding of the role for HIF-1α-regulated pathways in fibrotic disease will accelerate development of novel therapeutic strategies that target HIF-1α. Such new therapeutic strategies may be particularly effective for treatment of the prototypic, multisystem fibrotic, autoimmune disease SSc.
Reference Key
xiong2017frontierstargeting Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Anji Xiong;Yi Liu
Journal chemical research in chinese universities
Year 2017
DOI
10.3389/fphar.2017.00326
URL
http://journal.frontiersin.org/article/10.3389/fphar.2017.00326/full
Keywords
targeted therapy fibrosis hypoxia inducible factor pharmacology systemic sclerosistherapeutics

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