new insights about treg and th17 cells in hiv infection and disease progression

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ID: 138487
2015
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Abstract
Treg and Th17 cell subsets are characterized by the expression of specific transcriptional factors and chemokine receptor as well as by secretion of specific cytokine and chemokines. These subsets are important to the differentiation, expansion, homing capacity, and recruitment of several different immune cell populations to the site of infection. Whereas Treg cells maintain self-tolerance and control the activation and expansion of autoreactive CD4+ T effector cells through an anti-inflammatory response, Th17 cells, in an exacerbated unregulated proinflammatory response, can promote autoimmunity. Despite such apparently opposite functions, Th17 and Treg cells share common characteristics, and their differentiation pathways are interconnected. Recent studies have revealed quite intricate relations between Treg and Th17 cells in HIV infection and progression to AIDS. Considering Treg cells, different subsets were already investigated in the context of HIV infection, indicating a fluctuation in the total number and frequency throughout the disease course. This review focuses on the recent findings regarding the role of regulatory T and Th17 cells in the context of HIV infection, highlighting the importance of the balance between these two subsets on disease progression.
Reference Key
valverde-villegas2015journalnew Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jacqueline María Valverde-Villegas;Maria Cristina Cotta Matte;Rúbia Marília de Medeiros;José Artur Bogo Chies
Journal journal of photochemistry and photobiology b, biology
Year 2015
DOI
10.1155/2015/647916
URL
http://dx.doi.org/10.1155/2015/647916
Keywords
immunologic diseases allergy

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