increased il17a, ifng, and foxp3 transcripts in moderate-severe psoriasis: a major influence exerted by il17a in disease severity
Clicks: 207
ID: 138477
2016
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
207 views
51 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #124 of 382 articles by views in polyhedron
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 382 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Psoriasis is a chronic and recurrent dermatitis, mediated by keratinocytes and T cells. Several proinflammatory cytokines contribute to formation and maintenance of psoriatic plaque. The Th1/Th17 pathways and some of IL-1 family members were involved in psoriasis pathogenesis and could contribute to disease activity. Therefore, we sought to analyse skin transcript levels of IL17A, IL22, RORC, IL8, IFNG, IL33, IL36A, FOXP3, and IL10 and correlate with clinic of patients with plaque-type psoriasis. In order to conduct that, we collected punch biopsies from lesional skin and obtained tissue RNA. After reverse transcription, qRT-PCR quantified the relative mRNA expression. The main results revealed increased transcripts levels of IL17A, IFNG, and FOXP3 in moderate-severe patients. Despite this, only IL17A can increase the chance to worsen disease severity. We also observed many significant positive correlations between each transcript. In conclusion, IL17A is elevated in lesional skin from psoriasis patients and plays crucial role in disease severity.
| Reference Key |
oliveira2016mediatorsincreased
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Priscilla Stela Santana de Oliveira;Michelly Cristiny Pereira;Simão Kalebe Silva de Paula;Emerson Vasconcelos Andrade Lima;Mariana Modesto de Andrade Lima;Rodrigo Gomes de Arruda;Wagner Luís Mendes de Oliveira;Ângela Luzia Branco Pinto Duarte;Ivan da Rocha Pitta;Moacyr Jesus Melo Barreto Rêgo;Maira Galdino da Rocha Pitta |
| Journal | polyhedron |
| Year | 2016 |
| DOI |
10.1155/2016/4395276
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.