effect of ageing on systemic inflammatory response in acute pancreatitis
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ID: 138272
2012
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Abstract
Elderly patients show increased incidence of multiple organ dysfunction in acute pancreatitis possibly due to bacterial translocation. This is associated with increased susceptibility to infections in older people. Several reports have related this increased susceptibility to a proinflammatory status called inflammaging, which decreases the capacity of the immunological system to respond to antigens. Cellular senescence also contributes to this low-grade chronic inflammation in older subjects. We discuss here the effect of ageing on systemic inflammation, focusing on that induced by acute pancreatitis and some of the mechanisms involved. It is important to understand the immunological changes in the elderly to adjust treatment strategies in order to reduce the morbidity and mortality associated with acute pancreatitis and other conditions that lead to systemic inflammation.
| Reference Key |
machado2012internationaleffect
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|---|---|
| Authors | ;Marcel Cerqueira Cesar Machado;Ana Maria Mendonça Coelho;Luiz Augusto Carneiro D’Albuquerque;Sonia Jancar |
| Journal | comments on inorganic chemistry |
| Year | 2012 |
| DOI |
10.1155/2012/270319
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| URL | |
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