(3s)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid from cichorium endivia. l induces apoptosis of human colorectal cancer hct-8 cells
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2012
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Abstract
Cichorium endivia. L, consumed either cooked or eaten raw in salads, is a popular kind of vegetable cultivated all around the World. Its components have been widely used in folk medicine in anti-inflammatory therapy. However, the anti-cancer activity of the components has never been reported. In this study, (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (1), an amino acid isolated from C. endivia. L, was found for the first time to show cytotoxic activity in colorectal cancer cell line HCT-8. Compound 1 at concentrations of 0.5–4 μM induced apoptosis of HCT-8 cells in a dose-dependent manner. The compound 1-induced apoptosis in HCT-8 cells was accompanied by the loss of mitochondrial membrane potential, the activation of caspase-3, caspase-8 and caspase-9, the up-regulation of Bax and the down-regulation of Bcl-2. In addition, compound 1 suppressed the activation of NF-κB, which acts as an inhibitor of apoptosis. Taken together, these results suggested that compound 1 could significantly induce apoptosis of HCT-8 cells through the suppression of NF-κB signaling pathway, and thus can be considered as a potential candidate for developing chemotherapeutic drugs against cancer.
| Reference Key |
wang2012molecules(3s)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic
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| Authors | ;Ai-Ping Wang;Hai-Lin Qin;Ming Li;Jin-Feng Wei;An-Jun Deng;Fu-Xin Wang |
| Journal | Journal of ethnopharmacology |
| Year | 2012 |
| DOI |
10.3390/molecules18010418
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