diabetic kidney disease: is there a non-albuminuric phenotype in type 2 diabetic patients?
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2016
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Abstract
Background: Albuminuria was widely considered as the first clinical sign of diabetic kidney disease (DKD), which is why it has traditionally been used as a screening test for DKD. However, increasing evidence has shown that a significant number of type 2 diabetes mellitus (DM) patients have a decreased glomerular filtration rate (GFR) without significant albuminuria, known as non-albuminuric DKD (NA-DKD). The aim of this study was to determine the prevalence and the demographic and clinical characteristics of patients with NA-DKD.
Methods: This was a 1-year retrospective study that included 146 type 2 diabetic patients with GFR < 75 mL/min followed-up in a diabetes outpatient department. Patients were divided into two groups according to their ACR status – NA-DKD and albuminuric DKD (A-DKD).
Results: Of the 146 patients included in the study, 53.4% had A-DKD and 46.6% had NA-DKD. According to the multivariable analysis performed, patients with NA-DKD tended to be older (p = 0.021), female (p = 0.045) and with a lower GFR (p = 0.004) than A-DKD patients.
There was no difference between the groups in terms of body mass index, metabolic control of DM, duration of DM diagnosis and prevalence of metabolic syndrome.
Conclusions: The majority of patients with DKD had albuminuria, but a significant proportion had a non-albuminuric phenotype (46.6% in this population). These patients exhibit distinct clinical features that could have screening, therapeutic and prognosis implications.
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| Reference Key |
laranjinha2016nefrologadiabetic
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|---|---|
| Authors | ;Ivo Laranjinha;Patrícia Matias;Sofia Mateus;Filipa Aguiar;Patrícia Pereira;Miguel Perneta Santos;Rui Costa;Ana Lourenço;José Guia;José Diogo Barata;Luís Campos |
| Journal | european journal of preventive cardiology |
| Year | 2016 |
| DOI |
10.1016/j.nefro.2016.03.025
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| URL | |
| Keywords |
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