increase of eeg spectral theta power indicates higher risk of the development of severe cognitive decline in parkinson’s disease after 3 years

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ID: 137557
2016
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Abstract
Objective: We investigated quantitative electroencephalography (qEEG) and clinical parameters as potential risk factors of severe cognitive decline in Parkinson’s disease.Methods: We prospectively investigated 37 patients with Parkinson’s disease at baseline and follow-up (after 3 years). Patients had no severe cognitive impairment at baseline. We used a summary score of cognitive tests as the outcome at follow-up. At baseline we assessed motor, cognitive, and psychiatric factors; qEEG variables (global relative median power spectra) were obtained by a fully automated processing of high-resolution EEG (256-channels). We used linear regression models with calculation of the explained variance to evaluate the relation of baseline parameters with cognitive deterioration.Results: The following baseline parameters significantly predicted severe cognitive decline: global relative median power theta (4-8 Hz), cognitive task performance in executive functions and working memory.Conclusions: Combination of neurocognitive tests and qEEG improves identification of patients with higher risk of cognitive decline in PD.
Reference Key
cozac2016frontiersincrease Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Vitalii V Cozac;Menorca Chaturvedi;Menorca Chaturvedi;Florian Hatz;Antonia Meyer;Peter Fuhr;Ute Gschwandtner
Journal Frontiers in chemistry
Year 2016
DOI
10.3389/fnagi.2016.00284
URL
http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00284/full
Keywords
Cohort study EEG parkinson's disease cognitive decline neuropsychiatry biological psychiatry cognitive testsneurosciences

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