evaluation of the purified fraction of wilbrandia (c. f. ) verticillata for antitumour activity

تقييم الفعالية المضادة للأورام للجزء المُنقى من نبات *Wilbrandia (c. f.) verticillata*

Clicks: 307
ID: 137307
1991
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Abstract
Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).
تُعرف مركبات الكوكوربيتاسين بقدرتها على إظهار فاعلية سامة للخلايا ومضادة للسرطان. وقد عُزل حديثاً اثنان من جلوكوزيدات النوركوكوربيتاسين الجديدة (Wvl و Wv2) من جزء مُنقّى تم الحصول عليه من جذامير نبات *Wilbrandia verticillata*. تُقيّم الدراسة الحالية الفاعلية السامة للخلايا والمضادة للأورام لمركبات النوركوكوربيتاسين هذه. وقد أظهرت النتائج وجود سمية خلوية منتظمة في خلايا KB ‏(Cy50 = 12 µg/ml)، بالإضافة إلى تثبيط ملحوظ في نمو السرطانة اللحمية ووكر 256 (بحوالي 75%).
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rao1991memriasevaluation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;V. S. N. Rao;F. R. C. Almeida;A. P. Moraes;J. V. Silva;S. C. Nascimento;M. O. Moraes
Journal kurdistan journal of applied research
Year 1991
DOI
10.1590/S0074-02761991000600012
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600012
Keywords
Cytotoxicity antitumor tropical medicinemicrobiology

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